Pharmacokinetics and Pharmacodynamics of Efavirenz and Nelfinavir in HIV-infected Children Participating in an Area-under-the-curve Controlled Trial

Abstract

Fifty human immunodeficiency virus (HIV)‐infected children participated in an area‐under‐the plasma concentration–time curve (AUC)‐controlled trial of efavirenz and nelfinavir. Pharmacokinetic evaluations were performed at weeks 2, 6, and 56. Efavirenz and nelfinavir doses were adjusted to achieve AUC values of 60–120 and ⩾10 mg h/l, respectively. Thirty‐seven (74%) children met the efavirenz target and 41 (82%) the nelfinavir by week 10. Children with AUC values for both drugs above the first quartile were more likely to reach Clinical Pharmacology & Therapeutics (2008) doi:10.1038/sj.clpt.6100282