Broad HIV-1 neutralization mediated by CD4-binding site antibodies
Top Cited Papers
- 26 August 2007
- journal article
- research article
- Published by Springer Nature in Nature Medicine
- Vol. 13 (9), 1032-1034
- https://doi.org/10.1038/nm1624
Abstract
We have identified several patient sera showing potent and broad HIV-1 neutralization. Using antibody adsorption and elution from selected gp120 variants, the neutralizing specificities of the two most broadly reactive sera were mapped to the primary receptor CD4–binding region of HIV-1 gp120. Novel antibodies to the CD4-binding site are elicited in some HIV-1–infected individuals, and new approaches to present this conserved region of gp120 to the immune system may result in improved vaccine immunogens.Keywords
This publication has 21 references indexed in Scilit:
- Dissecting the Neutralizing Antibody Specificities of Broadly Neutralizing Sera from Human Immunodeficiency Virus Type 1-Infected DonorsJournal of Virology, 2007
- Structural definition of a conserved neutralization epitope on HIV-1 gp120Nature, 2007
- Aiming to induce broadly reactive neutralizing antibody responses with HIV-1 vaccine candidatesExpert Review of Vaccines, 2006
- HIV vaccine design and the neutralizing antibody problemNature Immunology, 2004
- Fine Mapping of the Interaction of Neutralizing and Nonneutralizing Monoclonal Antibodies with the CD4 Binding Site of Human Immunodeficiency Virus Type 1 gp120Journal of Virology, 2003
- HIV-specific CD8+ T cell proliferation is coupled to perforin expression and is maintained in nonprogressorsNature Immunology, 2002
- Antibody Protects Macaques against Vaginal Challenge with a Pathogenic R5 Simian/Human Immunodeficiency Virus at Serum Levels Giving Complete Neutralization In VitroJournal of Virology, 2001
- The HIV-1 Envelope Glycoproteins: Fusogens, Antigens, and ImmunogensScience, 1998
- Immunization with Envelope Subunit Vaccine Products Elicits Neutralizing Antibodies against Laboratory-Adapted but Not Primary Isolates of Human Immunodeficiency Virus Type 1The Journal of Infectious Diseases, 1996
- Neutralization of Divergent HIV-1 Isolates by Conformation-Dependent Human Antibodies to Gp120Science, 1991