What Does Brain Thyrotropin-Releasing Hormone Do?

Abstract

IN this issue of the Journal^,1 Faden and his colleagues report that thyrotropin-releasing hormone (TRH) dramatically ameliorates the neurologic consequences of spinal-cord injury in cats. This finding has both specific and general implications. Specifically, it holds promise for the treatment of cord trauma in human beings. Generally, it adds to the already imposing list of properties of TRH.TRH and several other hypothalamic peptides that regulate the secretion of several pituitary hormones have been isolated and characterized within the past 10 to 12 years. It soon became evident that these peptides were present not only in hypothalamic tissue but . . .