Adverse Effects of Phenobarbital on Corticosteroid Metabolism in Patients with Bronchial Asthma
- 25 May 1972
- journal article
- clinical trial
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 286 (21), 1125-1128
- https://doi.org/10.1056/nejm197205252862103
Abstract
The effects of phenobarbital therapy on plasma kinetics of labeled dexamethasone were investigated in 11 asthmatic patients. Phenobarbital caused a mean decrease in half-life of 117 minutes (-44 per cent) and an increase in metabolic clearance rate of 272 liters per day (+88 per cent). Urinary radioactivity excretion rate rose, the greatest increase occurring in the unconjugated ethyl acetate fraction. Increased urinary 6-hydroxycortisol excretion supported the presence of hepatic enzyme induction. These effects were not noted in five placebo-treated patients.Keywords
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