The structure of a plasmid of Chlamydia trachomatis believed to be required for growth within mammalian cells
- 1 July 1988
- journal article
- research article
- Published by Wiley in Molecular Microbiology
- Vol. 2 (4), 531-538
- https://doi.org/10.1111/j.1365-2958.1988.tb00060.x
Abstract
Sequence analysis of a 7.5 kb DNA plasmid isolated from Chlamydia trachomatis shows 8 open reading frames (ORFs) regularly spaced along most of the sequence. One of these ORFs encodes a 451-amino-acid polypeptide highly homologous to the DnaB protein of Escherichia coli. A region between ORFs 6 and 7 contains a cluster of alternating ATs and a 22 bp sequence tandemly repeated 4 times, suggesting a replication control region. Several ORFs correspond to plasmid-specific polypeptides that have been described. Codons ending with A or T are more frequent, as might be expected from the high A/T content (64%) of the plasmid, and codon usage is similar to that of the C. trachomatis chromosomal gene, omp1L2.This publication has 20 references indexed in Scilit:
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