The Induction of Cytolytic T Lymphocytes with Purified Plasma Membranes
- 1 April 1978
- journal article
- research article
- Published by The American Association of Immunologists in The Journal of Immunology
- Vol. 120 (4), 1114-1120
- https://doi.org/10.4049/jimmunol.120.4.1114
Abstract
Subcellular fractions were demonstrated to be effective in stimulating primary and secondary allogeneic CTL responses. 5′ nucleotidase activity was used to assess purification of plasma membranes and stimulating activity was found to co-purify with the plasma membrane fraction of the cell. Electron micrographs of these purified plasma membranes showed the majority of the material to be in the form of vesicles of relatively heterogeneous size. The cytolytic T lymphocytes generated by incubation with purified plasma membranes demonstrated immunologic specificity.This publication has 6 references indexed in Scilit:
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