GENETICALLY CONDITIONED METABOLIC ANTAGONISM AND SUPPRESSOR ACTION IN Neurospora
- 15 June 1955
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 41 (6), 364-369
- https://doi.org/10.1073/pnas.41.6.364
Abstract
A mutant strain of Neurospora crassa which grows like wild-type strains at 35[degree]C but which is markedly inhibited by the amino acid l-threonine requires the thiazole moiety of thiamine at lower temperatures of incubation for normal growth. The basis of the thiazole requirement may be a competitive antagonism between threonine and homocysteine. The requirement for thiazole is suppressed by introduction of a genetic block to threonine biosynthesis. The relation of these observations to possible mechanisms of genetic blocks to biosynthesis and suppressor action is discussed.Keywords
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