Adjuvant Interferon Treatment and the Late Development of Cerebral Metastases in a Patient with Osteosarcoma

Abstract

A consecutive series of patients with osteosarcoma have been receiving adjuvant interferon therapy at the Karolinska Hospital in Stockholm. We report here a case of tibial chondroblastic Grade III osteosarcoma, a boy aged 17 years, who received interferon therapy for 15 months and survived more than 5 years. the first sign of tumour spread was multiple cerebral metastases—an observation suggesting an antitumour effect of human leucocyte interferon on osteosarcoma.