Relationship Between the Lactic Dehydrogenase-Elevating Virus and Transplantable Murine Tumors.

Abstract

Summary The following murine tumors were propagated serially in vitro: Sarcoma 180, Hauschka-Klein ascites tumor, and hepa-tomas 129 and 134. The lactic dehydrogenase-elevating virus initially associated with all of these tumors in vivo did not multiply in cell cultures and by serial propagation in vitro the tumors were freed from the virus. The results indicate that the relationship between the lactic dehydrogenase-elevating virus and transplantable mouse tumors is that of a common contaminant. The “virus-free” tumor cells produced tumors when implanted into mice. The growth rate and transplant-ability of these tumors was the same in normal mice and in mice infected intentionally with the virus.