Role of Zinc in Interleukin 2 (IL‐2)‐Mediated T‐Cell Activation
- 1 May 1990
- journal article
- research article
- Published by Wiley in Scandinavian Journal of Immunology
- Vol. 31 (5), 547-552
- https://doi.org/10.1111/j.1365-3083.1990.tb02805.x
Abstract
In a serum‐free culture containing no zinc, zinc enhanced the proliferation of T cells in response to interleukin 2 (lL‐2), and also the in vitro production of lL‐2 by T cells. Although the lymphocyte proliferation was partially inhibited by anti‐IL‐2 antibodies, it was completely inhibited by anti‐IL‐2 receptor (CD25) antibodies. A Scatchard plot analysis showed that zinc induced the expression of high‐affinity receptors for IL‐2 on lymphocytes. The results indicated that zinc may be essentially required for IL‐2‐mediated T‐cell activation.This publication has 17 references indexed in Scilit:
- Zinc inhibits pokeweed mitogen-induced development of immunoglobulin-secreting cells through augmentation of both CD4 and CD8 cellsInternational Journal of Immunopharmacology, 1989
- Zinc fingers: Gilt by associationCell, 1988
- Induction of interferon-γ in human leukocyte cultures stimulated by Zn2+Clinical Immunology and Immunopathology, 1987
- Zinc in DNA Replication and TranscriptionAnnual Review of Nutrition, 1987
- Supplemental zinc (Zn2+) restores antibody formation in cultures of aged spleen cells II. Effects on mediator productionEuropean Journal of Immunology, 1987
- Low and high affinity cellular receptors for interleukin 2. Implications for the level of Tac antigen.The Journal of Experimental Medicine, 1984
- Severe Zinc Deficiency in Humans: Association with a Reversible T-Lymphocyte DysfunctionAnnals of Internal Medicine, 1981
- Zinc-induced activation of human B lymphocytesClinical Immunology and Immunopathology, 1980
- EFFECT OF ZINC ON THYMUS OF RECENTLY MALNOURISHED CHILDRENThe Lancet, 1977
- Stimulation of human peripheral lymphocytes by Zn2+ in vitroExperimental Cell Research, 1970