SYNTHESIS AND OPIATE ACTIVITY OF HUMAN β‐ENDORPHIN ANALOGS WITH VARIOUS CHAIN LENGTHS
- 1 July 1978
- journal article
- research article
- Published by Wiley in International Journal of Peptide and Protein Research
- Vol. 12 (1), 42-46
- https://doi.org/10.1111/j.1399-3011.1978.tb02866.x
Abstract
The synthesis of .beta.h[human]-endorphin [.beta.h-EP] -(1-15), -(1-21), -(1-26), -(1-28) and -(1-29) was accomplished by the solid-phase method. The opiate activities of the peptides were measured in the guinea pig ileum assay. Their relative potencies were .beta.h-EP, 1.00; Met-enkephalin, 0.25; .beta.h-EP-(1-15), 0.17; .beta.h-EP-(1-21), 0.46; .beta.h-EP-(1-26), 0.48; .beta.h-EP-(1-28), 0.89, .beta.h-EP-(1-29), 1.04.Keywords
This publication has 23 references indexed in Scilit:
- Analgesic activity of lipotropin C fragment depends on carboxyl terminal tetrapeptideNature, 1977
- β-Endorphin: Structure-activity relationships in the guinea pig ileum and opiate receptor binding assaysBiochemical and Biophysical Research Communications, 1977
- C fragment of lipotropin has a high affinity for brain opiate receptorsNature, 1976
- Isolation and structure of an untriakontapeptide with opiate activity from camel pituitary glands.Proceedings of the National Academy of Sciences, 1976
- Identification of two related pentapeptides from the brain with potent opiate agonist activityNature, 1975
- Action of plasmin on ovine beta-lipotropin: Revision of the car☐yl terminal sequenceBiochemical and Biophysical Research Communications, 1973
- The Preparation of Merrifield‐Resins Through Total Esterification With Cesium SaltsHelvetica Chimica Acta, 1973
- REVISED STRUCTURE OF SHEEP BETA‐LIPOTROPIC HORMONEInternational Journal of Peptide and Protein Research, 1972
- The effects of adrenaline, noradrenaline and isoprenaline on inhibitory α‐ and β‐adrenoceptors in the longitudinal muscle of the guinea‐pig ileumBritish Journal of Pharmacology, 1970
- A Method of Synthesis of Long Peptide Chains Using a Synthesis of Oxytocin as an ExampleJournal of the American Chemical Society, 1959