DETECTION OF THE CIRCULATING ANTIBODIES TO TERATOCARCINOMA-DEFINED ANTIGENS IN PATIENTS WITH TESTICULAR-TUMORS

  • 1 January 1980
    • journal article
    • research article
    • Vol. 40 (3), 438-444
Abstract
Sera from 23 patients with primary or metastatic testicular tumors of germinal origin were tested for antibodies against teratocarcinoma-associated antigen(s) using an indirect immunofluorescence technique. Human and 129/Sv mouse sperm and mouse teratocarcionma cell line 402 AX were used as target cells. Sera (15) were identified as positive, 6 of them when tested against sperm and tumor cells. Tail staining was the most prevalent pattern of fluorescence on human and murine spermatozoa. Antibody to a common teratoma-defined antigen(s) was apparently detected in sera of patients with testicular tumors.