Genome scan of a second wave of NIMH genetics initiative bipolar pedigrees: chromosomes 2, 11, 13, 14, and X
- 7 February 2003
- journal article
- research article
- Published by Wiley in American Journal Of Medical Genetics Part B-Neuropsychiatric Genetics
- Vol. 119B (1), 69-76
- https://doi.org/10.1002/ajmg.b.10063
Abstract
As part of the on-going NIMH Genetics Initiative on Bipolar Disorder, we have ascertained 153 multiplex bipolar pedigrees and genotyped them in two waves. We report here the genome scan results for chromosomes 2, 11, 13, 14, and X in the second wave of 56 families. A total of 354 individuals were genotyped and included in the current analyses, including 5 with schizoaffective/bipolar (SA/BP), 139 with bipolar I disorder (BPI), 41 with bipolar II disorder (BPII), and 43 with recurrent unipolar depression (RUP). Linkage analyses were carried out with multi-point parametric and non-parametric affected relative pair methods using three different definitions of the affected phenotype: (model 1) SA/BP and BPI; (model 2) SA/BP, BPI, and BPII; and (model 3) SA/BP, BPI, BPII, and RUP. The best findings were on 11p15.5 (NPL = 2.96, P = 0.002) and Xp11.3 (NPL = 2.19, P = 0.01). These findings did not reach conventional criteria for significance, but they were located near regions that have been identified in previous genetic studies of bipolar disorder. The relatively modest but consistent findings across studies may suggest that these loci harbor susceptibility genes of modest effect in a subset of families. Large samples such as that being collected by the NIMH Initiative will be necessary to examine the heterogeneity and identify these susceptibility genes.Keywords
This publication has 63 references indexed in Scilit:
- Manic-depression genes and the new millennium: poised for discoveryMolecular Psychiatry, 2002
- Are schizophrenic and bipolar disorders related? A review of family and molecular studiesBiological Psychiatry, 2000
- Schizophrenia susceptibility loci on chromosomes 13q32 and 8p21Nature Genetics, 1998
- Comprehensive Human Genetic Maps: Individual and Sex-Specific Variation in RecombinationAmerican Journal of Human Genetics, 1998
- Methodological problems in meta-analysis of association studies between bipolar affective disorder and the tyrosine hydroxylase geneAmerican Journal of Medical Genetics, 1998
- Further tests for linkage of bipolar affective disorder to the tyrosine hydroxylase gene locus on chromosome 11p15 in a new series of multiplex British affective disorder pedigrees [published erratum appears in Am J Psychiatry 1997 Jan;154(1):139]American Journal of Psychiatry, 1996
- Diagnostic Interview for Genetic StudiesArchives of General Psychiatry, 1994
- Diminished support for linkage between manic depressive illness and X–chromosome markers in three Israeli pedigreesNature Genetics, 1993
- X-Chromosome Markers and Manic-Depressive IllnessArchives of General Psychiatry, 1990
- Genetic linkage between X-chromosome markers and bipolar affective illnessNature, 1987