In Vitro Histamine Release from Sensitized Rabbit Blood Cells. Evidence Against Participation of Fibrinolysin
- 1 April 1950
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 73 (4), 605-609
- https://doi.org/10.3181/00379727-73-17759
Abstract
The authors investigated the importance of fibrinolysin in the release of histamine by antigen from the blood cells of the sensitized rabbit in vitro. Fibrinolysin probably is not essential in such histamine release because soybean trypsin inhibitor (STI) and bovine antifibrinolysin failed to inhibit the histamine release, and purified bovine fibrinolysin is a very poor histamine release agent in comparison to trypsin and antigen. After the failure of STI to inhibit the release of histamine by antigen there was in the plasma a sufficient excess of STI to inhibit histamine release by trypsin.Keywords
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