Association of Paroxysmal Nocturnal Hemoglobinuria with Erythroleukemia

Abstract

PAROXYSMAL nocturnal hemoglobinuria (PNH)¹ and erythroleukemia² are both characterized by acquired abnormalities of red blood cells and also feature involvement of other hematopoietic cell lines. With recent reports of PNH terminating in myelogenous leukemia,^{3 4 5} Dameshek⁶ hypothesized that PNH may fit into the category of myeloproliferative diseases and, indeed, be a variant of erythroleukemia.This report describes the concomitant occurrence of PNH and erythroleukemia. Such an association is a logical link in the progression of PNH to acute leukemia.Case ReportL.G., a 32-year-old man, was transferred to Wilford Hall USAF Medical Center in July, 1969, with the diagnosis of PNH. . . .