Congenital Heart Disease in Relation to Maternal Use of Bendectin and Other Drugs in Early Pregnancy
- 8 August 1985
- journal article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 313 (6), 347-352
- https://doi.org/10.1056/nejm198508083130603
Abstract
To clarify the association of Bendectin and other drugs used in early pregnancy with the occurrence of congenital heart disease, we interviewed 298 mothers of children with congenital heart disease and 738 mothers of healthy controls. Differential recall of drug use by mothers of affected children and mothers of controls was evaluated by comparison of information collected by interview with that recorded in the prenatal record. Data derived from maternal interviews were generally consistent with the record data. Reported Bendectin use was minimally associated with congenital heart disease (prevalence odds ratio, 1.1; 90 per cent confidence interval, 0.8 to 1.5).Keywords
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