Deletion analysis of male sterility effects oft–haplotypes in the mouse

Abstract

Summary: We present data on the effects of three chromosome 17 deletions on transmission ratio distortion (TRD) and sterility of severalt-haplotypes. All three deletions have similar effects on male TRD: that is,T^del/t^completegenotypes all transmit theirt–haplotype in very high proportion. However, each deletion has different effects on sterility of heterozygous males, withT^or/tbeing fertile,T^hp/tless fertile, andT^orl/tstill less fertile. These data suggest that wild-type genes on chromosomes homologous to f-haplotypes can be important regulators of both TRD and fertility in males, and that the wild-type genes concerned with TRD and fertility are at least to some extent different. The data also provide a rough map of the positions of these genes.