Physiologic Disposition of Methohexital in Man

Abstract

Some factors that influence the course of clinical anesthesia with methohexital in man were investigated. The rate of biotransformation of methohexital and the extent of its ibnization are in the same range as but somewhat higher than those for thiopental. In binding to plasma proteins it is identical with thiopental. Its lipid solubility is high enough to permit rapid passage across the blood-brain barrier, but its accumulation in fat is less extensive than that of thiopental or methitural.