TRAUMATIC SHOCK. XVII. PLASMA FIBRINOGEN IN HEMORRHAGIC SHOCK IN THE DOG

Abstract

No alteration in plasma fibrinogen concn. was observed in hemorrhagic shock, apart from what can be attributed to hemodilution or transfusion. The observed changes are insufficient to interfere with blood coagulation. Complete defibrinogenation was achieved by intravascular admn. of thrombin. Defibrinogenated, but otherwise normal, dogs show no bleeding tendency except in fresh wounds. Regeneration of plasma fibrinogen is rapid. In shock there is no regeneration of fibrinogen unless there is a favorable response to transfusion, in which case fibrinogen regeneration is markedly delayed.