THE EFFECT OF BENEMID (P-[DI-N-PROPYLSULFAMYL]-BENZOIC ACID) ON URIC ACID METABOLISM IN ONE NORMAL AND ONE GOUTY SUBJECT 12

Abstract

In both subjects the oral ingestion of 2 g. Benemid daily caused a marked decrease in the uric acid pool size and an increase in the turnover rate. The "extra" uric acid excreted in the exptl. periods exceeded the drop in the pool size perhaps because some of the excreted uric acid was derived from uric acid depots or because the amt. of uric acid contributed by the diet was altered during the drug periods. In the control period on the non-gouty subject only 71.5% of the injected N15_uric acid was recovered as urinary uric acid up to the time when its excretion ceased. During Benemid therapy this recovery increased to 89.6%. The recovery in the total of both periods in the gouty subject was 98.9%.