Cytomegalic Inclusion Disease of Lacrimal Glands in Male Laboratory Rats.

Abstract
Cytomegalic inclusion disease of intraorbital and exorbital lacrimal glands was observed in adult male rats from 8 laboratory colonies but was not seen in any females nor in wild urban or rural Norway rats. Affected acinar cells showed characteristic eosinophilic intranuclear inclusion bodies and subsequent cytomegaly. Bizarre nuclear patterns simulated neoplastic morphology in late stages of the disease.