Role of the Rep Helicase Gene in Homologous Recombination in Neisseria gonorrhoeae
Open Access
- 15 April 2005
- journal article
- Published by American Society for Microbiology in Journal of Bacteriology
- Vol. 187 (8), 2903-2907
- https://doi.org/10.1128/jb.187.8.2903-2907.2005
Abstract
In Escherichia coli , the Rep helicase has been implicated in replication fork progression, replication restart, homologous recombination, and DNA repair. We show that a Neisseria gonorrhoeae rep mutant is deficient in the homologous-recombination-mediated processes of DNA transformation and pilus-based colony variation but not in DNA repair.Keywords
This publication has 43 references indexed in Scilit:
- A Mutant Form of the Neisseria gonorrhoeae Pilus Secretin Protein PilQ Allows Increased Entry of Heme and Antimicrobial CompoundsJournal of Bacteriology, 2004
- Roles of therecJandrecNGenes in Homologous Recombination and DNA Repair Pathways ofNeisseria gonorrhoeaeJournal of Bacteriology, 2002
- Viability of rep recA Mutants Depends on Their Capacity To Cope with Spontaneous Oxidative Damage and on the DnaK Chaperone ProteinJournal of Bacteriology, 2001
- The size and position of heterologous insertions in a silent locus differentially affect pilin recombination in Neisseria gonorrhoeaeMolecular Microbiology, 1996
- Lethality of rep recB and rep recC double mutants of Escherichia coliMolecular Microbiology, 1995
- dinP, a new gene in Escherichia coli, whose product shows similarities to UmuC and its homologuesMutation Research Letters, 1995
- Multiple gonococcal pilin antigenic variants are produced during experimental human infections.JCI Insight, 1994
- RecQ DNA Helicase of Escherichia coli: Characterization of the Helix-unwinding Activity with Emphasis on the Effect of Single-stranded DNA-binding ProteinJournal of Molecular Biology, 1993
- Intragenic recombination leads to pilus antigenic variation in Neisseria gonorrhoeaeNature, 1985
- The rep mutation: IV. Slower movement of replication forks in Escherichia coli rep strainsJournal of Molecular Biology, 1975