Chromosomal site of hepatitis B virus (HBV) integration in a human hepatocellular carcinoma-derived cell line
- 1 January 1985
- journal article
- research article
- Published by S. Karger AG in Cytogenetic and Genome Research
- Vol. 39 (2), 116-120
- https://doi.org/10.1159/000132118
Abstract
The single site of integration of hepatitis B virus in the human hepatocellular carcinoma cell line Hep 3B 2-1/7 was found to segregate with human chromosome 12 in somatic cell hybrids. Analysis of metaphase spreads of Hep 3B 2-1/7 following in situ hybridization with pHBV revealed integration at 12q13→q14, a location that coincides with a fragile site, fra (12q13). The possible significance of this location to the development of hepatocellular carcinomas is discussed.Keywords
This publication has 2 references indexed in Scilit:
- Localization of single copy DNA sequences on G-banded human chromosomes by in situ hybridizationChromosoma, 1981
- State of hepatitis B viral DNA in a human hepatoma cell lineJournal of Virology, 1980