Amphetamine-like reactions to phenylpropanolamine

Abstract

Phenylpropanolamine hydrochloride is an amphetamine-like substance that is found in 64 different over-the-counter preparations for colds and appetite suppression. It is also found in numerous prescription drugs. Recently, it was reported to cause symptoms of sympathomimetic-like effects, such as severe hypertension, hypertensive crisis and possible renal failure. Also, several cases of psychotic episodes while taking phenylpropanolamine were reported. This is the report of 7 patients who have experienced acute CNS effects. These effects range from stimulation of the medullary respiratory center to tremor, restlessness, increased motor activity, agitation and hallucinations.