Amiodarone Interaction With β-Blockers
- 4 May 1999
- journal article
- clinical trial
- Published by Wolters Kluwer Health in Circulation
- Vol. 99 (17), 2268-2275
- https://doi.org/10.1161/01.cir.99.17.2268
Abstract
Background—Investigations with in vitro and animal models suggest an interaction between amiodarone and β-blockers. The objective of this work was to explore if an interaction with β-blocker treatment plays a role in the decrease of cardiac arrhythmic deaths with amiodarone in patients recovered from an acute myocardial infarction. Methods and Results—A pooled database from 2 similar randomized clinical trials, the European Amiodarone Myocardial Infarction Trial (EMIAT) and the Canadian Amiodarone Myocardial Infarction Trial (CAMIAT), was used. Four groups of post–myocardial infarction patients were defined: β-blockers and amiodarone used, β-blockers used alone, amiodarone used alone, and neither used. All analyses were done on an intention-to-treat basis. Unadjusted and adjusted relative risks for all-cause mortality, cardiac death, arrhythmic cardiac death, nonarrhythmic cardiac death, arrhythmic death, or resuscitated cardiac arrest were lower for patients receiving β-blockers and amiodarone than for t...Keywords
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