EFFECTS OF 5‐HYDROXYTRYPTAMINE ON CANINE ISOLATED CORONARY ARTERIES

Abstract

1 The effects of 5-hydroxytryptamine (5-HT) were studied in vitro on proximal and distal portions of canine interventricular and circumflex coronary arterial strips. 5-HT produced concentration-related contractions in the proximal portion whether contracted previously with KCl or not. These responses were still present after either chemical sympathetic denervation or release of noradrenaline induced by K⁺-free salt solution. In contrast, the distal portions of coronary arteries did not respond to 5-HT. 2 Concentration-response curves to 5-HT exhibited a classical hyperbolic shape with a calculated Hill-coefficient of approximately 1. 3 Methysergide and phentolamine but not morphine shifted to the right and depressed the maximum of the dose-response curves to 5-HT. 4 It is concluded that the contractions produced by 5-HT in the proximal portion of the interventricular and circumflex coronary arteries are not due to the release of endogenous noradrenaline. The vessels appear to possess separate receptors for 5-HT and noradrenaline and the 5-HT responses belong to neither the M nor the D type.