Cross Talk between Wnt/β-Catenin and CIP2A/Plk1 Signaling in Prostate Cancer: Promising Therapeutic Implications
- 1 June 2016
- journal article
- review article
- Published by Taylor & Francis in Molecular and Cellular Biology
- Vol. 36 (12), 1734-1739
- https://doi.org/10.1128/mcb.00130-16
Abstract
Aberrant activation of the Wnt/β-catenin pathway and polo-like kinase 1 (Plk1) overexpression represent two common events in prostate cancer with relevant functional implications. This review analyzes their potential therapeutic significance in prostate cancer based on their role as androgen receptor (AR) signalling regulators and the pivotal role of the tumor suppressor protein phosphatase 2A (PP2A) modulating these pathways.Keywords
Funding Information
- Instituto de Salud Carlos III FEDER (PI13/02609, PI15/00934)
This publication has 109 references indexed in Scilit:
- Wnt/β-Catenin Signaling and DiseaseCell, 2012
- Activation of β-Catenin Signaling in Androgen Receptor–Negative Prostate Cancer CellsClinical Cancer Research, 2012
- Polo-like Kinase 1 Facilitates Loss of Pten Tumor Suppressor-induced Prostate Cancer FormationJournal of Biological Chemistry, 2011
- RNAi-based Therapeutics Targeting Survivin and PLK1 for Treatment of Bladder CancerMolecular Therapy, 2011
- Wnt/β-Catenin activation promotes prostate tumor progression in a mouse modelOncogene, 2010
- Targeted Depletion of Polo-Like Kinase (Plk) 1 Through Lentiviral shRNA or a Small-Molecule Inhibitor Causes Mitotic Catastrophe and Induction of Apoptosis in Human Melanoma CellsJournal of Investigative Dermatology, 2009
- PR55α, a Regulatory Subunit of PP2A, Specifically Regulates PP2A-mediated β-Catenin DephosphorylationJournal of Biological Chemistry, 2009
- Plk1-mediated Phosphorylation of Topors Regulates p53 StabilityJournal of Biological Chemistry, 2009
- Crosstalk between the Androgen Receptor and β-Catenin in Castrate-Resistant Prostate CancerCancer Research, 2008
- Suppression of Wnt/β-catenin signaling inhibits prostate cancer cell proliferationEuropean Journal of Pharmacology, 2008