COMPLEMENT ACTIVITY IN MIDDLE-EAR EFFUSIONS

  • 1 January 1978
    • journal article
    • research article
    • Vol. 33 (2), 340-346
Abstract
Evidence for complement utilization in middle ear fluids (MEF) from patients with otitis media with effusion was sought. Cleavage products of C[complement component]3, C4 and factor B could be demonstrated immunochemically in MEF, and native C3 was present in much lower concentrations than other proteins, relative to their serum concentrations. Hemolytic assays for C1-C5 showed that early complement components were inactivated in MEF. Potential mechanisms for complement utilization in MEF were discussed.