Relationship between Cell-Interaction and Antiviral Activity of Polyriboinosinic Acid-Polyribocytidylic Acid in Different Cell Cultures

Abstract

Interaction of [³H]-labelled poly(rI).poly(rC) with the cell has been studied in several cell cultures which differ markedly in their sensitivity to the antiviral activity of the polynucleotide (in order of decreasing sensitivity): primary rabbit kidney (PRK) cells, human skin fibroblasts (HSF), mouse embryo fibroblasts (MEF), mouse L-929 cells, rabbit kidney (RK 13) cells, HeLa, BSC-1 and VERO cells.