Structure Activity Relationship Among 6-Substituted-2-Naphthylacetic Acids: A New Series of Nonsteroidal Anti-inflammatory Agents
- 1 January 1973
- journal article
- research article
- Published by Taylor & Francis in Scandinavian Journal of Rheumatology
- Vol. 2 (sup2), 7-11
- https://doi.org/10.3109/03009747309097090
Abstract
Chemical modification of 2-naphthylacetic acid has led to (+)-2-(6-methoxy-2-naphthyl)-propionic acid, naproxen. Maximal biological activity in the naph-thylpropionic acid series is associated with the S absoiuti configuration. In experimental animals naproxen shows anti-inflammatory, analgetic and antipyretic activity o: llxphenylbutazone, and 7 and 22xacetylsalicylic acid re spectively. It is noteworthy that highly active compound! were obtained without resorting to nitrogenous substitu cnts.Keywords
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