Over one third of US smokers attempt cessation each year1-5; however, the success rate per attempt is low.2,6,7 Few smokers seek assistance for cessation,3,8,9 and those who do tend to be more dependent.3,9,10 During the 1990s, following clinical trials indicating efficacy, a variety of pharmaceutical cessation aids became available.11-19 Designed to lessen nicotine withdrawal symptoms (eg, anxiety, irritability, intense craving), these aids were recommended as adjuvants to behavioral therapies.11-14 In the controlled-trial setting, with well-monitored protocols, nicotine replacement therapy (NRT) and the antidepressant bupropion increased success for moderate to heavy smokers (≥15 cigarettes/d) by 50% to 100%.11-18 There is no consensus of a benefit for light smokers (<15 cigarettes/d).