Initiation and promotion at different ages and doses in 2200 mice. II. Decrease in promotion by TPA with ageing
Open Access
- 1 July 1981
- journal article
- research article
- Published by Springer Nature in British Journal of Cancer
- Vol. 44 (1), 15-23
- https://doi.org/10.1038/bjc.1981.142
Abstract
The effects of various treatment timings and doses [of 12-O-tetradecanoylphorbolacetate (TPA)] given at different ages were compared. Initiation with DMBA [dimethylbenzanthracene] at 68 wk of age, followed 3 wk later by TPA, has a significantly (P < 0.0001) less rapid effect on subsequent tumor incidence than does initiation at 8 or at 48 wk of age, followed 3 wk later by TPA. This is chiefly due not to changes in the numbers of cells initiated by DMBA but rather to a decrease in the promotional efficacy of TPA in aging mice.Keywords
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