Profiling model T-cell metagenomes with short reads
Open Access
- 9 January 2009
- journal article
- Published by Oxford University Press (OUP) in Bioinformatics
- Vol. 25 (4), 458-464
- https://doi.org/10.1093/bioinformatics/btp010
Abstract
Motivation: T-cell receptor (TCR) diversity in peripheral blood has not yet been fully profiled with sequence level resolution. Each T-cell clonotype expresses a unique receptor, generated by somatic recombination of TCR genes and the enormous potential for T-cell diversity makes repertoire analysis challenging. We developed a sequencing approach and assembly software (immuno-SSAKE or iSSAKE) for profiling T-cell metagenomes using short reads from the massively parallel sequencing platforms.Keywords
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