The chemotherapy of rodent malaria. XLVII. Studies on pyronaridine and other Mannich base antimalarials
- 1 January 1992
- journal article
- research article
- Published by Taylor & Francis in Pathogens and Global Health
- Vol. 86 (5), 455-465
- https://doi.org/10.1080/00034983.1992.11812694
Abstract
The activities of Mannich base antimalarials, including pyronaridine, have been explored against drug-sensitive (Plasmodium berghei N) and chloroquine-resistant (Plasmodium yoelii NS) rodent malaria parasites in vivo. Lines of these parasites have been developed with resistance to pyronaridine, amodiaquine, or WR 228,258. The responses and patterns of cross-resistance of these lines to Mannich bases and other blood schizontocides are inconsistent. It is concluded that some Mannich bases may prove still to be of value in the treatment of chloroquine-resistant Plasmodium falciparum infection.Keywords
This publication has 11 references indexed in Scilit:
- Molecular genetics of drug resistance in Plasmodium faiciparum malariaParasitology Today, 1991
- Pyronaridine: A new antimalarial drugParasitology Today, 1991
- Positive relationship between the response of Plasmodium falciparum to chloroquine and pyronaridineTransactions of the Royal Society of Tropical Medicine and Hygiene, 1991
- In vitro activity of artemisinin, its derivatives, and pyronaridine against different strains of Plasmodium falciparumTransactions of the Royal Society of Tropical Medicine and Hygiene, 1990
- Disposition of amopyroquin in rats and rabbits and in vitro activity against Plasmodium falciparumAntimicrobial Agents and Chemotherapy, 1988
- Amodiaquine as a prodrug: Importance of metabolite(s) in the antimalarial effect of amodiaquine in humansLife Sciences, 1985
- The chemotherapy of rodent malaria, XXXVIIPathogens and Global Health, 1984
- The chemotherapy of rodent malaria, XXX. The enigmas of the ‘NS lines’ ofP. bergheiPathogens and Global Health, 1978
- The chemotherapy of rodent malaria, XXIIIPathogens and Global Health, 1975
- The chemotherapy of rodent malaria, XXIIPathogens and Global Health, 1975