Palladium-Phosphinous Acid Catalyzed Cross-Coupling of Aryl Halides Using a Hypervalent Phenylsilane in Water

Abstract

A palladium-phosphinous acid catalyzed NaOH-promoted cross-coupling methodology that affords biaryls from tetrabutylammonium triphenyldifluorosilicate and aryl halides in good to high yields has been developed. The coupling proceeds in aqueous 0.5 M NaOH solution in the absence of organic co-solvents and does not require inert atmosphere, which greatly facilitates operation and catalyst handling.