α‐Lipoic acid inhibits TNF‐a‐induced NF‐κB activation and adhesion molecule expression in human aortic endothelial cells
Open Access
- 1 November 2001
- journal article
- research article
- Published by Wiley in The FASEB Journal
- Vol. 15 (13), 2423-2432
- https://doi.org/10.1096/fj.01-0260com
Abstract
Endothelial activation and monocyte adhesion are initiating steps in atherogenesis thought to be caused in part by oxidative stress. The metabolic thiol antioxidant a-lipoic acid has been suggested t...Keywords
Funding Information
- National Institutes of Health (HL-56170, HL-60886)
This publication has 58 references indexed in Scilit:
- Inhibition of Tumor Necrosis Factor-α– and Interleukin-1–Induced Endothelial E-Selectin Expression by Thiol-Modifying AgentsArteriosclerosis, Thrombosis, and Vascular Biology, 1998
- Notoginsenoside R1 Counteracts Endotoxin-Induced Activation of Endothelial Cells In Vitro and Endotoxin-Induced Lethality in Mice In VivoArteriosclerosis, Thrombosis, and Vascular Biology, 1997
- Sequential observation of micrometastasis formation by bacterial lacZ gene-tagged Lewis lung carcinoma cellsCancer Letters, 1997
- Inhibition of NF-κB Activation in Human T-Cell Lines by AnetholdithiolthioneBiochemical and Biophysical Research Communications, 1996
- Transient Overexpression of Catalase Does Not Inhibit TNF- or PMA-Induced NF-κB ActivationBiochemical and Biophysical Research Communications, 1995
- Increased expression in vivo of VCAM-1 and E-selectin by the aortic endothelium of normolipemic and hyperlipemic diabetic rabbits.Arteriosclerosis and Thrombosis: A Journal of Vascular Biology, 1994
- Function and Activation of NF-kappaB in the Immune SystemAnnual Review of Immunology, 1994
- Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigmCell, 1994
- Antioxidant activity of dihydrolipoate against microsomal lipid peroxidation and its dependence on α-tocopherolBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1989
- Interplay between lipoic acid and glutathione in the protection against microsomal lipid peroxidationBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1988