Carcinoma of the gallbladder, a rare condition in 1850, has since become a common one. The apparent increase in the incidence of the disease roughly parallels the increase in the frequency of operations on the gallbladder. The purpose of this paper is to add to the literature the data on 48 cases of carcinoma of the gallbladder observed at the New York Hospital from 1915 to 1935. After a brief historical review, the cases are analyzed pathologically, the pathogenesis being emphasized whenever possible. The same cases are then considered clinically in an attempt to clarify the clinical picture and thereby to aid in early diagnosis. HISTORICAL REVIEW In 1777 Maximilian Stoll,1 of Vienna, published the first authentic record of carcinoma of the gallbladder, reporting 2 cases in which autopsy was performed. His first case not only introduced a new group of diseases but was unique, the patient having situs