Titration of sodium channels in canine gastric mucosa.
- 1 September 1975
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 72 (9), 3731-3734
- https://doi.org/10.1073/pnas.72.9.3731
Abstract
Net Na+ flux from mucosa to lumen, potential difference, and volume and plasma protein outputs were measured in vagally denervated, separated pouches of the dog's oxyntic or pyloric glandular mucosa when the pouches were irrigated with Na+-free solutions whose pH ranged from 1.5 to 12.2. The apparent permeability to Na+(P'Na) was calculated. P'Na is lowest when the mucosa is bathed with acid and increases 2- to 3-fold when the pH is raised to 10. In the range of pH 10.0--11.2 P'Na is greater by an order of magnitude, but volume output is small, and no plasma proteins are shed. When the pH is above 11.2 there is an abrupt increase in P'Na, and the mucosa sheds a large volume of fluid containing plasma proteins. The change effected by raising the pH to the range of 10.0--11.2 occurs within 10 sec, and it is reversible. The change effected by raising the pH above 11.2 also occurs within 10 sec, and it is partly reversible.Keywords
This publication has 17 references indexed in Scilit:
- Plasma Proteins in Canine Gastric LymphGastroenterology, 1975
- An essential ionized acid group in sodium channelsPublished by Springer Nature ,1975
- Discrimination of monovalent inorganic cations by “tight” junctions of gallbladder epitheliumThe Journal of Membrane Biology, 1974
- Route of Protein Loss During a Model Protein-Losing Gastropathy in DogsGastroenterology, 1974
- Protein-Losing Gastropathy Produced by Sulfhydryl ReagentsGastroenterology, 1971
- Fluid produced by the gastric mucosa during damage by acetic and salicylic acidsGastroenterology, 1966
- Functional Significance of Gastric Mucosal Barrier to SodiumGastroenterology, 1964
- The influence of acid on the gastric absorption of water, sodium and potassiumThe Journal of Physiology, 1963
- Microscopic dimensions of the pit region of the dog's gastric mucosa.1958
- The effect of sodium fluoride on the output of some electrolytes from the gastric mucosa of catsThe Journal of Physiology, 1956