The First Proline of PALP Motif at the C Terminus of Presenilins Is Obligatory for Stabilization, Complex Formation, and γ-Secretase Activities of Presenilins
Open Access
- 1 August 2001
- journal article
- Published by Elsevier
- Vol. 276 (35), 33273-33281
- https://doi.org/10.1074/jbc.m011152200
Abstract
No abstract availableKeywords
This publication has 52 references indexed in Scilit:
- Total inactivation of γ–secretase activity in presenilin-deficient embryonic stem cellsNature Cell Biology, 2000
- Presenilins are required for γ-secretase cleavage of β-APP and transmembrane cleavage of Notch-1Nature Cell Biology, 2000
- Translating cell biology into therapeutic advances in Alzheimer's diseaseNature, 1999
- A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domainNature, 1999
- Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor proteinNature, 1998
- Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease geneNature, 1995
- Amyloid β protein (Aβ) deposition: Aβ42(43) precedes Aβ40 in down SyndromeAnnals of Neurology, 1995
- Visualization of Aβ42(43) and Aβ40 in senile plaques with end-specific Aβ monoclonals: Evidence that an initially deposited species is Aβ42(43)Neuron, 1994
- An Increased Percentage of Long Amyloid β Protein Secreted by Familial Amyloid β Protein Precursor (βApp 717 ) MutantsScience, 1994
- Seeding “one-dimensional crystallization” of amyloid: A pathogenic mechanism in Alzheimer's disease and scrapie?Cell, 1993