Uptake of 2'-amino-2'-deoxyguanosine by Escherichia coli and its competition by guanosine.
- 1 January 1977
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 30 (9), 736-742
- https://doi.org/10.7164/antibiotics.30.736
Abstract
The antibacterial activity of a new nucleoside antibiotic, 2''-amino-2''-deoxyguanosine (2AG), is reversed by guanosine and other purine nucleosides. 2AG is apparently taken up by E. coli by a mechanism different from that of guanosine; guanosine inhibits this uptake noncompetitively. Insensitive E. coli strains and the resistant mutant obtained from the sensitive strain took up 2AG.This publication has 3 references indexed in Scilit:
- A general method for the synthesis of 2'-azido-2'-deoxy- and 2'-amino-2'-deoxyribofuranosyl purinesThe Journal of Organic Chemistry, 1977
- Identification and Some Culture Conditions of 2′-Amino-2′- deoxyguanosine-producingEnterobacter cloacaeAgricultural and Biological Chemistry, 1977
- Identification of a novel aminonucleoside produced by Enterobacter sp. as 2'-amino-2'-deoxyguanosine.CHEMICAL & PHARMACEUTICAL BULLETIN, 1975