Nutritional Consequences of the Maillard Reaction. Amino Acid Availability from Fructose-leucine and Fructose-tryptophan in the Rat
- 1 May 1973
- journal article
- research article
- Published by Elsevier in Journal of Nutrition
- Vol. 103 (5), 657-663
- https://doi.org/10.1093/jn/103.5.657
Abstract
The biological availability of the Amadori compounds fructose-L-leucine and fructose-L-tryptophan was examined in weanling rats. Relative to 14C-L-leucine, the apparent absorbability of fructose-14C-L-leucine was about 60%, but the incorporation of its radioactivity in the liver was less than 1.5%. Oral administration of fructose-14C-L-tryptophan showed that only a small percentage of the radioactivity was absorbed and incorporated. The absorption occurred mostly in the large intestine and was largely prevented after pretreating the rat with antibiotics. Intravenous injection of fructose-14C-L-tryptophan resulted in an accumulation of the counts in the plasma while a negligible incorporation of counts took place in the liver. Although the essential amino acids were highly unavailable when supplied to the rat in the form of the Amadori compound, the fructose-tryptophan was preferable to the total absence of tryptophan from the diet as seen in the readiness of the liver polysomes to remain assembled as well as in the ability of the animal to recover. The effect of the intestinal flora was discussed in relation to the absorption and utilization of the Maillard reaction products.Keywords
This publication has 10 references indexed in Scilit:
- Digestion of Heat-damaged Egg Albumen by the RatJournal of Nutrition, 1970
- Availability of amino acids. Fructose-glycine as a source of nonspecific nitrogen for ratsJournal of Agricultural and Food Chemistry, 1970
- Availability of amino acids. A methionine-fructose compound and its availability to microorganisms and ratsJournal of Agricultural and Food Chemistry, 1968
- The digestion of heat-damaged proteinBritish Journal of Nutrition, 1967
- The effect of feeding with a tryptophan-free amino acid mixture on rat-liver polysomes and ribosomal ribonucleic acidBiochemical Journal, 1966
- Amino Acid Diets and Maximal Growth in the RatJournal of Nutrition, 1965
- Die Umsetzung von L‐Tryptophan und L‐Histidin mit Hexosen)European Journal of Inorganic Chemistry, 1964
- Ribosomal Aggregate Engaged in Protein Synthesis: Characterization of the ErgosomeNature, 1963
- A microbiological method for assessing the nutritional value of proteinsBritish Journal of Nutrition, 1962
- Preparation of 1-Amino-1-deoxy-2-ketohexoses from Aldohexoses and α-Amino Acids. I1Journal of the American Chemical Society, 1955