A PROPOSED COMMON ALLOSTERIC MECHANISM FOR ACTIVE TRANSPORT, MUSCLE CONTRACTION, AND RIBOSOMAL TRANSLOCATION
- 1 September 1969
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 64 (1), 267-274
- https://doi.org/10.1073/pnas.64.1.267
Abstract
It is suggested that active transport, muscle contraction, and ribosomal translocation may all make use of a common allosteric mechanism in which ATP or GTP serves as both the effector and substrate and in which a conformational change in a protein (enzyme) moves or exerts a force on a second ligand. The enzymatic splitting of ATP or GTP provides the driving force for the process and allows repetition of the steady-state cycle.Keywords
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