Partial Purification of an Opiate Receptor from Mouse Brain
- 22 February 1974
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 183 (4126), 749-753
- https://doi.org/10.1126/science.183.4126.749
Abstract
A proteolipid isolated from a lipid extract of mouse brain demonstrates stereospecific binding properties for levorphanol. It is present only in neuronal tissue and most abundant in the rhombencephalon. One component saturates at a concentration corresponding to maximum pharmacologic effect in vivo. The estimated mass is 60,000 daltons per bound opiate molecule.Keywords
This publication has 17 references indexed in Scilit:
- Stereospecific Interaction Between Narcotic Analgesics and a Synaptic Plasma Membrane Fraction of Rat Cerebral CortexActa Pharmacologica et Toxicologica, 1973
- Opiate Receptor: Demonstration in Nervous TissueScience, 1973
- Autoradiographic studies concerning the supraspinal site of the antinociceptive action of morphine when inhibiting the hindleg flexor reflex in rabbitsNeuropharmacology, 1973
- Fluorescamine: A Reagent for Assay of Amino Acids, Peptides, Proteins, and Primary Amines in the Picomole RangeScience, 1972
- Modification of the lowry procedure for the analysis of proteolipid proteinAnalytical Biochemistry, 1972
- Enhancement by morphine of the central descending inhibitory influence on spinal sensory transmissionEuropean Journal of Pharmacology, 1971
- Fractionation of lipids and proteolipids from cat grey and white matter by chromatography on an organophilic dextran gelJournal of Chromatography A, 1969
- Mode of Action of Morphine-like Drugs on Autonomic Neuro-effectorsNature, 1968
- LIPIDS AND PROTEOLIPIDS IN ISOLATED SUBCELLULAR MEMBRANES OF RAT BRAIN CORTEX*Journal of Neurochemistry, 1968
- Measurement of protein-binding phenomena by gel filtrationBiochimica et Biophysica Acta, 1962