Content and synthesis of hepatic pyridine nucleotides in fetal and neonatal rabbits
- 1 July 1965
- journal article
- research article
- Published by American Physiological Society in American Journal of Physiology-Legacy Content
- Vol. 209 (1), 215-220
- https://doi.org/10.1152/ajplegacy.1965.209.1.215
Abstract
The concentration and the synthesis of pyridine nucleotides in the liver and placenta of the rabbit have been studied as a function of developmental age. The concentration of total hepatic pyridine nucleotides increased progressively during fetal and neonatal development, reaching a maximal level in the adult period. This increase was due primarily to elevation in diphosphopyridine nucleotide (DPN) and reduced triphosphopyridine nucleotide (TPNH). In the postmature state, hepatic reduced diphosphopyridine nucleotide (DPNH) and triphosphopyridine nucleotide (TPN) levels were less than in term or 5-day-old rabbits. The concentration of total pyridine nucleotides in the placenta diminished during gestation. Following parenteral administration of nicotinamide to the pregnant rabbit, the concentration of nicotinamide increased to the same extent in maternal and fetal blood plasma and the total pyridine nucleotide concentration increased in both maternal and fetal liver. The latter increment was greater in maternal than in fetal liver, and in fetal liver was greatest at term. The increase was due largely to increase in DPN in the developing fetus and neonate, and in the adult rabbit to increase in all pyridine nucleotides.Keywords
This publication has 17 references indexed in Scilit:
- Respiratory enzymes in the liver of the newborn ratProceedings of the Royal Society of London. B. Biological Sciences, 1959
- Specific methods for the microdetermination of pyridine nucleotides and pyridine nucleotide enzymesArchives of Biochemistry and Biophysics, 1957
- PYRIDINE COENZYMES OF SUBCELLULAR TISSUE FRACTIONSJournal of Biological Chemistry, 1957
- Comparative rates of synthesis in diphosphopyridine nucleotide by normal and tumour tissue from mouse mammary gland: studies with isolated nucleiBiochemical Journal, 1956
- PYRIDINE NUCLEOTIDE SYNTHESIS IN THE MOUSEJournal of Biological Chemistry, 1956
- THE INTERMEDIARY METABOLISM OF HUMAN FETAL TISSUESCold Spring Harbor Symposia on Quantitative Biology, 1954
- Regulation of Blood Glucose in the Human FetusJournal of Applied Physiology, 1953
- INCORPORATION IN VITRO OF RADIOACTIVE CARBON FROM CARBOXYL-LABELED dl-ALANINE AND GLYCINE INTO PROTEINS OF NORMAL AND MALIGNANT RAT LIVERSJournal of Biological Chemistry, 1948
- A COLORIMETRIC METHOD FOR THE DETERMINATION OF DESOXYRIBONUCLEIC ACIDJournal of Biological Chemistry, 1947
- STUDIES IN FETAL METABOLISM1947