Charting HIV's remarkable voyage through the cell: Basic science as a passport to future therapy
- 1 July 2002
- journal article
- review article
- Published by Springer Nature in Nature Medicine
- Vol. 8 (7), 673-680
- https://doi.org/10.1038/nm0702-673
Abstract
Adequate control of HIV requires impairing the infection, replication and spread of the virus, no small task given the extraordinary capacity of HIV to exploit the cell's molecular machinery in the course of infection. Understanding the dynamic interplay of host cell and virus is essential to the effort to eradicate HIV.Keywords
This publication has 107 references indexed in Scilit:
- Segregation of CD4 and CXCR4 into Distinct Lipid Microdomains in T Lymphocytes Suggests a Mechanism for Membrane Destabilization by Human Immunodeficiency VirusJournal of Virology, 2002
- DC-SIGN-Mediated Internalization of HIV Is Required for Trans-Enhancement of T Cell InfectionImmunity, 2002
- Lipid Rafts and HIV Pathogenesis: Host Membrane Cholesterol Is Required for Infection by HIV Type 1AIDS Research and Human Retroviruses, 2001
- Tat Transactivation: A Model for the Regulation of Eukaryotic Transcriptional ElongationVirology, 1999
- Retroviruses as Model Systems for the Study of Nuclear RNA Export PathwaysVirology, 1998
- Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibodyNature, 1998
- HIV Entry and Its InhibitionCell, 1998
- In vivo evolution of HIV-1 co-receptor usage and sensitivity to chemokine-mediated suppressionNature Medicine, 1997
- Global distribution of the CCR5 gene 32-basepair deletionNature Genetics, 1997
- Homozygous Defect in HIV-1 Coreceptor Accounts for Resistance of Some Multiply-Exposed Individuals to HIV-1 InfectionCell, 1996