Metal(II) d-Tartrates Catalyzed Asymmetric Ring Opening of Oxiranes with Various Nucleophiles
- 1 April 1988
- journal article
- research article
- Published by Oxford University Press (OUP) in Bulletin of the Chemical Society of Japan
- Vol. 61 (4), 1213-1220
- https://doi.org/10.1246/bcsj.61.1213
Abstract
The asymmetric ring opening of meso-2,3-disubstituted oxiranes with thiols, aniline, and trimethylsilyl azide was studied by the use of metal(II) d-tartrates as heterogeneous chiral Lewis acid catalysts. The enantioselectivity varied widely with the combination of oxirane, nucleophile, and metal(II) d-tartrate, and Zn(II) d-tartrate gave the best enantioselectivity in the respective reactions of 1,2-epoxycyclohexane with 1-butanethiol, aniline, and trimethylsilyl azide to afford the corresponding adducts in 85, 58, and 42% ee, respectively. Furthermore, the kinetic resolution of racemic oxiranes with thiols catalyzed by Zn(II) d-tartrate was studied.Keywords
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