Structure, sequence and expression of the hepatitis delta (δ) viral genome
- 9 October 1986
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 323 (6088), 508-514
- https://doi.org/10.1038/323508a0
Abstract
Biochemical and electron microscopic data indicate that the human hepatitis δ viral agent contains a covalently closed circular and single-stranded RNA genome that has certain similarities with viroid-like agents from plants. The sequence of the viral genome (1,678 nucleotides) has been determined and an open reading frame within the complementary strand has been shown to encode an antigen that binds specifically to antisera from patients with chronic hepatitis δ viral infections.Keywords
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