Inhibitors of human neutrophil elastase as a potential treatment for inflammatory diseases
- 1 July 1999
- journal article
- Published by Informa Healthcare in Expert Opinion on Therapeutic Patents
- Vol. 9 (7), 851-868
- https://doi.org/10.1517/13543776.9.7.851
Abstract
Inhibition of human neutrophil elastase (HNE), (EC 3.4.21.37), as an approach to the treatment of inflammatory diseases in the chronic obstructive pulmonary disease (COPD) continuum, such as emphysema and chronic bronchitis, is still an area of intense research within the pharmaceutical industry. This review summarises some recent developments in the design and evaluation of HNE inhibitors as therapeutic agents since the subject was last reviewed in this publication in 1997.Keywords
This publication has 42 references indexed in Scilit:
- Syntheses of trans-5- Oxo-hexahydro-pyrrolo[3,2-b]pyrroles and trans-5-Oxo-hexahydro-furo[3,2-b]pyrroles (Pyrrolidine trans-Lactams and trans-Lactones): New Pharmacophores for Elastase InhibitionJournal of Medicinal Chemistry, 1998
- Potent selective thienoxazinone inhibitors of herpes proteasesBioorganic & Medicinal Chemistry Letters, 1997
- Recombinant Elastase Inhibitors for TherapyAnnals of the New York Academy of Sciences, 1991
- Mucus proteinase inhibitor: a fast-acting inhibitor of leucocyte elastaseBiochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1989
- Human leukocyte and porcine pancreatic elastase: x-ray crystal structures, mechanism, substrate specificity, and mechanism-based inhibitorsBiochemistry, 1989
- Replacement Therapy for Alpha1-Antitrypsin Deficiency Associated with EmphysemaNew England Journal of Medicine, 1987
- Alpha1-Antitrypsin Deficiency and Emphysema Caused by Homozygous Inheritance of Non-Expressing Alpha1-Antitrypsin GenesNew England Journal of Medicine, 1986
- Elastolytic activity of sputum and its relation to purulence and to lung function in patients with bronchiectasis.Thorax, 1984
- On the size of the active site in proteases. I. PapainBiochemical and Biophysical Research Communications, 1967
- The Electrophoretic α;1-Globulin Pattern of Serum in α;1-Antitrypsin DeficiencyScandinavian Journal of Clinical and Laboratory Investigation, 1963