Telomerase is required to slow telomere shortening and extend replicative lifespan of HSCs during serial transplantation
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Open Access
- 15 July 2003
- journal article
- Published by American Society of Hematology in Blood
- Vol. 102 (2), 517-520
- https://doi.org/10.1182/blood-2002-07-2334
Abstract
Telomere shortening ultimately limits the replicative life span of cultured human somatic cells. Telomeres also shorten during replicative aging in vKeywords
This publication has 22 references indexed in Scilit:
- The telomerase reverse transcriptase is limiting and necessary for telomerase function in vivoCurrent Biology, 2000
- Extension of Life-Span by Introduction of Telomerase into Normal Human CellsScience, 1998
- Telomerase Catalytic Subunit Homologs from Fission Yeast and HumanScience, 1997
- Telomerase Activity in Hematopoietic Cells Is Associated with Self-Renewal PotentialImmunity, 1996
- Heterogeneity in telomere length of human chromosomesHuman Molecular Genetics, 1996
- Differential Expression of Telomerase Activity in Hematopoietic Progenitors from Adult Human Bone MarrowThe International Journal of Cell Cloning, 1996
- Evidence for a mitotic clock in human hematopoietic stem cells: loss of telomeric DNA with age.Proceedings of the National Academy of Sciences, 1994
- Telomere reduction in human colorectal carcinoma and with ageingNature, 1990
- Loss of proliferative capacity in immunohemopoietic stem cells caused by serial transplantation rather than aging.The Journal of Experimental Medicine, 1978
- Decline in colony‐forming ability of marrow cells subjected to serial transplantation into irradiated miceJournal of Cellular and Comparative Physiology, 1964