Microiontophoretic studies of the effects of false transmitter candidates and amphetamine on cerebellar Purkinje cells
- 1 June 1975
- journal article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 27 (6), 408-412
- https://doi.org/10.1111/j.2042-7158.1975.tb09469.x
Abstract
The effects of microiontophoretic applications of equivalent doses (ejection times and currents) of noradrenaline, amphetamine, octop-amine and p-hydroxynorephedrine on the spontaneous firing of Purkinje and unidentified cells in the cerebellum of rats were examined. In addition, the effects of amphetamine on Purkinje cells were examined in nimals pretreated with the tyrosine hydroxylase inhibitor, α-methyl-tyrosine (α-MpT) or with a combination of reserpine plus α-MpT. The results indicate that the “false transmitters” are weak agonists when compared to noradrenaline in inhibiting the firing of Purkinje cells. The results of the iontophoretic studies with amphetamine are not consistent with a pre-synaptic releasing effect by amphetamine at noradrenergic synapses in the cns since the efficacy of amphetamine on Purkinje cells was unaltered after pretreatment with α-MpT or α-MpT plus reserpine.Keywords
This publication has 16 references indexed in Scilit:
- Enhanced sensitivity of caudate neurones to microiotophoretic injections of dopamine in 6-hydroxydopamine treated catsBrain Research, 1972
- Acetylcholine inhibition in the intact and chronically isolated cerebral cortexBritish Journal of Pharmacology, 1972
- A neuronal basis for the alerting action of (+)‐amphetamineBritish Journal of Pharmacology, 1972
- Biosynthesis of Cerebral Phenolic Amines. I. In Vivo Formation of p-Tyramine, Octopamine, and SynephrineCanadian Journal of Biochemistry, 1972
- Studies on norepinephrine-containing afferents to Purkinje cells of rat cerebellum. II. Sensitivity of Purkinje cells to norepinephrine and related substances administered by microiontophoresisBrain Research, 1971
- On the Presence of p‐Hydroxynorephedrine in the Rat Brain and Heart in Relation to Changes in Catecholamine Levels after Administration of AmphetamineActa Pharmacologica et Toxicologica, 1971
- Tissue concentrations of p-hydroxynorephedrine in rats injected with d-amphetamine: Effect of pretreatment with desipramineLife Sciences, 1969
- The conversion in vivo of d-amphetamine to (+)-p-hydroxynorephedrineBiochimica et Biophysica Acta (BBA) - General Subjects, 1965
- A sensitive method for spectrophotofluorometric assay of catecholaminesInternational Journal of Neuropharmacology, 1964
- Excitatory and inhibitory processes acting upon individual Purkinje cells of the cerebellum in catsThe Journal of Physiology, 1956